| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c4423185f79003e8f9b981e29323454a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-233
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-90 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-59 |
| filingDate |
2012-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9a6e91ee52f09d1ff0487978b7e21a5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fbcf433fd3a4bd5eb9561b6a2fba827
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b21044576ab46780e56c0f599d9fb2bd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6beccffb5be5001a02677e1b3f453737 |
| publicationDate |
2016-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
NZ-624328-A |
| titleOfInvention |
Process for preparing quinoline derivatives |
| abstract |
Disclosed herein is a process for preparing a compound of Formula I, comprising the steps: wherein: R1 is halo; R2 is halo; R3 is (C1-C6)alkyl or (C1-C6)alkyl optionally substituted with heterocycloalkyl; R4 is (C1-C)alkyl; and Q is CH or N; comprising: (a) contacting 1,1 -cyclopropane dicarboxylic acid with thionyl chloride in a polar aprotic solvent; (b) adding and a tertiary amine base to the mixture of step (a) to form a compound of Formula A; and (c) coupling a compound of Formula A with an amine of Formula B to form a compound of Formula I. |
| priorityDate |
2011-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |