| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_324f02bbaa9087f036e446bb1c3183a3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-08 |
| filingDate |
2012-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e05572b798b158cfa1a4e0087ea33a14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5ccfadd39cb8a771407637219fb5d35 |
| publicationDate |
2016-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
NZ-624019-A |
| titleOfInvention |
Method for inhibition of deubiquitinating activity |
| abstract |
Disclosed herein are compounds of the formula S-1 where the substituents are as defined herein. Examples of the compounds include (3E, 5E)‐3,5‐Bis(phenylmethylidene)azepan‐4‐one and (3E,5E)‐5‐[(4‐chlorophenyl)methylidene]‐3‐[(4‐nitrophenyl)methylidene]azepan‐4‐one. The compounds are capable of abrogating the deubiquitinating (DUB) activity of the 19S RP DUBs and are therefore suitable for treating cancer, in particular of cancer refractory to treatment by chemotherapy using compounds such as bortezomib. Also disclosed are corresponding methods of treatment and pharmaceutical compositions comprising the compounds. |
| priorityDate |
2011-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |