| abstract |
Disclosed herein are pharmaceutical compositions comprising at least one hydrophobic camptothecin derivative, such as the compounds of formula I, or a pharmaceutically acceptable salt of said derivative and a polyethylene glycol (PEG) conjugated phospholipid. Also disclosed are methods for inhibiting cancer cells in a subject in need thereof by administering the pharmaceutical composition of the present invention. An example of the camptothecin derivatives of formula I is the compound (S)-10-[(dimethylamino)methyl]-4-ethyl-9-hydroxy-4-O-[(±)-2-(2”,4”,5”,7”-tetranitro-9”-fluorenylideneaminooxy)propionyl]-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione. |