http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-618984-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_063b06db59be3c8d81dc83feb734b48a |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2008-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a7b1b2a8b552914bf4862dc6a626553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f423bf27fe64dd23a715f50bf12465f2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc9893235d9a38aa0316713ad3de2bf7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f53f1c8489eb9ab070840f0379f521b |
| publicationDate | 2015-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-618984-A |
| titleOfInvention | Pharmaceutical compositions of rhein or diacerein |
| abstract | Disclosed is a modified release pharmaceutical composition comprising rhein (4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid, Formula I) or diacerein (diacetylrhein, 4,5-diacetyloxy-9,10-dioxo-anthracene-2-carboxylic acid, Formula II), or salts or esters thereof, wherein the modified release comprises combination of extended release or delayed release with immediate release. The modified releases are achieved by one or more functional coatings or mixing the rhein or diacerein, or salts or esters thereof with one or more pharmaceutically acceptable polymers, wherein the composition exhibits a dissolution profile such that more than 70% of diacerein is released within 60 minutes, wherein the release rate is measured in Apparatus 2 (USP, Dissolution, paddle, 75 rpm) using 1000 ml of pH 5.7 phosphate buffer at 37°C ± 0.5°C. Also disclosed is a process for preparing a modified release composition by combining rhein or diactylrhein with one or more pharmaceutically acceptable polymers, optionally with other pharmaceutical excipients and converting the mixture into a suitable dosage form. |
| priorityDate | 2007-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.