| abstract |
The disclosure relates to a non-peptidyl polymer-insulin multimer, comprising two or more of a non-peptidyl polymer-insulin conjugate prepared by linking a nonpeptidyl polymer and insulin via a covalent bond, wherein the conjugates are complexed with a trivalent cobalt ion to form a multimer. The non-peptidyl polymer is a biodegradable polymer, a lipid polymer, chitin, a hyaluronic acid, or combinations thereof. If it is the biodegradable polymer, it is selected from the group consisting of polyethylene glycol, polypropylene glycol, ethylene glycol-propylene glycol copolymer, polyoxyethylated polyol, polyvinyl alcohol, polysaccharide, dextran, polyvinyl ethyl ether, polylactic acid, and polylactic-glycolic acid. The disclosure also relates to a method and kit for the preparation of the multimer, a pharmaceutical composition for the prevention or treatment of diabetes comprising the multimer as an active ingredient, and the use of the multimer for preventing or treating diabetes. |