| abstract |
Disclosed herein is the use of a combination of a thiazide diuretic; the organic anion transporter 4 (OAT4) inhibitor 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid (lesinurad) or a pharmaceutically acceptable salt thereof and allopurinol in the manufacture of a medicament for use in the treatment of gout, hyperuricemia or reducing serum uric acid levels in a patient suffering from hypertension. The thiazide diuretic is selected from hydrochlorothiazide, bendroflumethiazide, benzothiadiazine, hydroflumethiazide, clorothiazide, methyclothiazide, polythiazide, chlorthalidone, metolazone, indapamide, bumetanide, ethacrynic acid, furosemide or torsemide. |