| abstract |
The disclosure relates to purine derivative compounds as inhibitors of Heat Shock Protein 90 (HSP90) of general Formula (IA) and (IB), wherein the substituents are as described in the specification. Compositions comprising an effective amount of a Compound of Formula (IA) or (IB), and methods to treat or prevent a condition, such as cancer which overexpresses Her-kinases, comprising administering to an patient in need thereof a therapeutically effective amount of a Compound of Formula (IA) or (IB) or a pharmaceutically acceptable salt thereof. The disclosure further relates to compounds of Formula (IA) and (IB) in which X2 is a leaving group such as trialkyl tin or SN(CH2CH2(CF2)5CF3)3 for introducing a radiolabeled atom, such as 124I or 131I, and to methods of using such compounds in the preparation of radiolabeled compounds, particularly for use in imaging. |