| abstract |
616558 Disclosed is a Process for the synthesis of the compound of formula (I), 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, characterised in that the compound of formula (VIII), 3-(4,5-dimethoxyphenyl)propanenitrile is subjected to the action of N-bromosuccinimide in the presence of an organic solvent to yield the compound of formula (I). Compound of formula (I) is useful in the preparation of ivabradine, 3-{ 3-[{ [(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl} (methyl)amino]propyl} -7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one. |