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filingDate 2012-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2016-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber NZ-615579-A
titleOfInvention Novel protein purification methods
abstract Disclosed are methods of reducing fouling of an ultrafiltration membrane in a process wherein virus particles are removed from an aqueous solution comprising said virus particles and a monoclonal antibody, the method comprising the steps of: a) adding to said aqueous solution a non-ionic surfactant, and b) filtering said aqueous solution comprising said surfactant through said ultrafiltration membranes, wherein the presence of said surfactant in said aqueous solution reduces fouling of said ultrafiltration membrane, wherein the addition of said surfactant to said aqueous solution enhances the filtration throughput efficiency of said ultrafiltration membrane by at least 10%; wherein said non-ionic surfactant is selected from the group consisting of polysorbate 20, t-octylphenoxypolyethoxyethanol, polyoxyethylene (40) isooctylphenyl ether, and lauromacrogol.
priorityDate 2011-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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