| abstract |
Disclosed are pyrrolo[2,3-d]pyrimidine compounds of Formula (I) wherein the substituents are as described in the specification, which includes the compound N-(5-{ [2-amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-dlpyrimidin-5-yllcarbonyl} pyridin-3-yl)-2-[4-(trifluoromethyl)phenyllacetamide. Also disclosed are processes for the preparation of the compounds, compositions containing the compounds, and the uses of such compounds and salts in treating diseases or conditions associated with tropomyosin-related kinase (Trk), and activity. More specifically the invention relates to the compounds and their salts useful as inhibitors of Trk for the treatment of diseases or conditions such as pain and cancer. |