abstract |
Discloses a polypeptide capable of eliciting neutralising antibodies against a virus comprises a variant of HIV-1 gp120 or an immunogenic fragment thereof wherein the polypeptide comprises the C131Y, T132N, D138G and N160Y mutations with respect to the numbering of SEQ ID NO:2, wherein the sequence is as disclosed in the complete specification. Further discloses antibodies binding the mutant polypeptide and methods to detect pathogen in a sample using the mutant polypeptide. |