| abstract |
Provided are methods for producing an anti-4-hydroxypyrrolidine-3-carboxamide derivative or an enantiomer thereof, of general formula (II), where the variables are as described in the specification. The methods for producing the compounds are characterised by the asymmetric hydrogenation of a 4-oxopyrrolidine-3-carboxylic acid amide derivative, of general formula (I), where the variables are as described in the specification, using an optically active catalyst. Further provided are methods of preparing compounds of the formulas (III), (IV) and (V),where their variables are as described in the specification, used in the production of the anti-4-hydroxypyrrolidine-3-carboxamide derivatives. |