| abstract |
Disclosed herein is a pharmaceutical composition comprising rifaximin particles, wherein substantially all the particles have a particle size less than or equal to 2 micrometres and the use thereof for treating a bacterial infection. Additionally disclosed is a process for preparing the pharmaceutical composition comprising the steps of homogenizing rifaximin, at least one surface stabiliser, at least one viscosity building agent, and at least one polymer to produce a homogenized dispersion of the rifaximin in the surface active agent, the viscosity building agent and the polymer; milling said homogenized dispersion to produce a slurry of particles having a particle size less than or equal to 2 micrometres; and adsorbing the milled slurry on carrier to form granules. |