| abstract |
Disclosed is a substituted fused heterocycle of formula (I) where the substituents are as disclosed in the specification. nExamples of a compounds of formula (I) are: 1-[2-(1-Ethoxymethyl-piperidin-4-yloxy)-6,7 -dihydro-4-H-thiazolo[5,4-c]pyridin-5-yl]-propan-1-one; 1-{2-[1-(2,2,2-Trifluoro-ethyl)-piperidin-4-yloxy]-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-5-yl}-propan-1-one; 1-[2-(1-Cyclobutyl-azetidin-3-yloxy)-6,7-dihydro-4-H-thiazolo[5,4-c]pyridin-5-yl]-propan-1-one; 1-[2-(1-Cyclobutyl-pyrrolidin-3-yloxy)-4,6-dihydro-pyrrolo[4,3-d]thiazol-5-yl]-propan-1-one; and 1-[2-(1-Cyclobutyl-azepan-4-yloxy)-4,6-dihydro-pyrrolo[4,3-d]thiazol-5-yl]-propan-1-one. nAlso disclosed are pharmaceutical compositions comprising a compound of formula (I); the process for preparing a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament. The medicament is useful in the treatment of cognitive disorders, sleep disorders, obesity and pain. |