| abstract |
ABSTRACT - 604973 The disclosure relates to compounds corresponding to formula (I), preparation process and therapeutic use thereof, wherein R2 and R3 together form, with the carbon atoms of the phenyl nucleus to which they are attached, a 6-membered nitrogenous heterocycle corresponding to one of formula (A), (B) or (C), in which the wavy lines represent the phenyl nucleus to which R2 and R3 are attached, and the variables R1, R4, Ra, Ra’, Rb, Rb’, Rc, Rc’ and Rc” are as defined in the specification. These compounds inhibit FGF-induced angiogenesis and are suitable for the treatment and prevention of cardiovascular diseases and cancers, in particular carcinomas which have a high degree of vascularization, such as lung, breast, prostate, pancreatic, colon, kidney and oesophageal carcinomas, cancers which induce metastases, such as colon cancer, liver cancer and stomach cancer, melanomas, gliomas, lymphomas, leukaemias, and also thrombopenias. |