| abstract |
Disclosed herein are hexafluoroisopropyl carbamate derivatives, their preparation and their therapeutic application. An example of which is 2,2,2-trifluoro-1-(trifluoromethyl)ethyl 4-(5-chloro-2-oxo-2,3-dihydrobenzimidazol-1-yl)piperidine-1-carboxylate. The compounds have an inhibitory effect on enzyme MGL (monoacyl glycerol lipase) and are therefore intended for the treatment of conditions such as pain, metabolic disorders, allergic and inflammatory disorders. |