http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-603672-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-70 |
| filingDate | 2011-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ca232c66311031750d5290127f5260c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cfdc85422b2d79cd9cdf774b28ec4d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b15490a05104f1e064594f71388d389 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ae70ebf3085015e9c86a93f37afcb03 |
| publicationDate | 2015-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-603672-A |
| titleOfInvention | Process for preparing pyrimidinone compounds |
| abstract | Disclosed is a process for making a thio-substituted cyclopenta[d]pyrimidine compound of formula (I). The process comprising the steps of: (a) treating a C(1-4)alkyl 2-oxocyclopentanecarboxylate with an alkali metal salt of glycine to form a compound of formula (A) (b) cyclising a compound of said formula (A) to form the hexahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetic acid of formula (B) by treating a compound of said formula (A) with either: (i) a thiocyanate salt and (B) a) a haloalkylsilane and a proton source, with heating, or b) an anhydrous acid, with heating; or (ii) trimethylsilylisothiocyanate, with heating; (c) forming a thio-4-oxo-4,5,6,7-tetrahydro-lH-cyciopenta[d]pyrimidin-l-yl)acetic acid of formula (C) by treating a compound of said formula (B) with a thio-alkylating reagent which is a benzyl derivative of formula (D) (d) treating an aldehyde of formula (E) with an amine, a heavy metal catalyst and hydrogen to form a secondary amine of formula (F) (e) forming a compound of formula (I) by treating a compound of said formula (C) with carbonyldiimidazole and the secondary amine of formula (F) and heating the mixture. An example of a compound of formula (I) is: N-[2-(diethylamino)ethyl]-2-(2-{ [(4-fluorophenyl)methyl]thio} -4-oxo-4,5,6,7-tetrahydro-1H-cyciopenta[d]pyrimidin-1-yl)-N-{ [4’-(trifluoromethyl)-4-biphenylyl]methyl} acetamide. |
| priorityDate | 2010-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.