http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-603627-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cac023d2e2874224ecbbcccbdea1fc91 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B61-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-10 |
| filingDate | 2011-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b5bda44936b535e54cb0b83343dde02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_816ac168bcb0b52271a393c4e8a4e1f1 |
| publicationDate | 2014-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-603627-A |
| titleOfInvention | Method for producing 3-substituted-4-fluoropyrrolidine derivative |
| abstract | 603627 Disclosed is a method for producing a compound represented by the general formula (8) such as (benzyl (3R,4R)-3-(N-cyclopropyl-aminomethyl)-4-hydroxypyrrolidine-1-carboxylate) or it’s enantiomer, or their salts, comprising step 1 and step 2: (Step 1) a process of fluorinating a compound represented by the general formula (6) (such as benzyl (3R,4R)-3-(N-cyclopropyl-N-(2-nitrobenzenesulfonyl)aminomethyl)-4-hydroxypyrrolidine-1-carboxylate) or it’s enantiomer using a nucleophilic fluorinating agent (such as nonafluorobutane-1-sulfonyl fluoride) and an organic base having an amidine or guanidine structure (such as tetramethylguanidine, 1,8-diazabicyclo[5.4.0]undec-7-ene, or 1,5-diazabicyclo[4.3.0]non-5-ene); and (Step 2) a process of deprotecting a protecting group on the amino group of the compound represented by the general formula (7) or it’s enantiomer, or their salts obtained in step 1 using a thiol compound and a base, and wherein PG1 represents a protecting group for an amino group, R1 represents an alkyl group which may be substituted or a cycloalkyl group which may be substituted, and Ns represents a 2-nitrobenzenesulfonyl group or a 4-nitrobenzenesulfonyl group. |
| priorityDate | 2010-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.