| abstract |
A peptide conjugate having the formula I: R1 – Z – L – Y – R2 wherein R1 is H, C1-4 alkyl, acetyl, formyl, benzoyl or trifluoroacetyl; Z is a peptide sequence having the formula IVa His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Z9-Leu-Ser-Z12-GI n-Met-Glu-Z 16-Glu-Ala-Val-Arg-Leu-PheIle- Glu-Trp-Leu-Z27-Z28 (IVa) wherein Z9 is selected from Glu and Asp; Z12 is selected from Lys and Orn; Z16 is selected from Glu and Lys; Z27 is selected from Lys and Orn; Z28 is selected from Asn and Asp or is absent; L is a peptide sequence having the formula IVb L 1-L2-L3-L4 (IVb) wherein L 1 is selected from Peg3, Gin, Cys, Lys and Orn or is absent; L2 is selected from Peg3, Gin, Cys, Lys and Orn or is absent; L3 is selected from Peg3, Gin, Cys, Lys and Orn or is absent; L4 is selected from Peg3, Gin, Cys, Lys and Orn or is absent; Y is a peptide sequence having the formula IVc Y12-Y13-Trp-Leu-Asp-Phe (IVc) wherein Y12 is Tyr or is absent; and Y13 is Gly or is absent; or a pharmaceutically acceptable salt or solvate thereof. |