| abstract |
Disclosed is a pharmaceutical composition comprising efavirenz in the form of particles, wherein substantially all the particles have a particle size less than or equal to 1 micrometre (1 micron). Further disclosed is a process for preparing a pharmaceutical composition, which process comprises the steps of: homogenizing efavirenz, at least one surface stabilizer, at least one viscosity building agent, and at least one polymer to produce a homogenized dispersion of the efavirenz in the surface active agent, the viscosity building agent and the polymer; milling said homogenized dispersion to produce a slurry of particles having a particle size less than or equal to 1 micrometre; and adsorbing the milled slurry on a carrier to form granules. Also disclosed is a pharmaceutical composition comprising efavirenz in the form of particles, wherein substantially all the particles have a particle size less than or equal to 1 micrometre, for use in the treatment of HIV. |