| abstract |
Disclosed are prodrugs of methyl hydrogen fumarate (monomethyl fumarate) according to formula (II), and methods for their preparation. Specific examples of compounds of formula (II) include: ethoxycarbonyloxyethyl methyl (2E)but-2-ene-1,4-dioate, methyl phenylcarbonyloxyethyl (2E)but-2-ene-1,4-dioate, cyclohexylcarbonyloxybutyl methyl (2E)but-2-ene-1,4-dioate, and methyl (2-methylpropanoyloxy)ethyl (2E)but-2-ene-1,4-dioate. Compounds of formula (II) are useful for treating psoriasis, multiple sclerosis, an inflammatory bowel disease, asthma, chronic obstructive pulmonary disease or arthritis. |