| abstract |
600954 Disclosed herein is a compound of formula I, wherein the variables are defined in the specification, the use of said compound for inhibiting PI3K-gamma kinase activity, and the use of said compound for treating autoimmune disease or an inflammatory disease of the brain or spinal cord selected from multiple sclerosis, epilepsy, Parkinson's disease, Alzheimer's disease, Huntington's disease, or amyotrophic lateral sclerosis. Embodiments of the compound include the following: 2-(5-methoxy-3-pyridyl)-4-methyl-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]spiro[pyrrolo[3,4-b]pyridine-7,3'-tetrahydrofuran]-5-one, 2-(5,6-dimethoxy-3-pyridyl)-7-methyl-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-7H-pyrrolo[3,4-b]pyridin-5-one, and 6-(1-(2-(1H-pyrazol-1-yl)ethyl)-1H-pyrazol-4-yl)-2-(5,6-dimethoxypyridin-3-y1)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one. |