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publicationDate 2014-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber NZ-600358-A
titleOfInvention Topical foam composition
abstract 600358 A topical foam pharmaceutical composition for rectal administration comprising rifaximin in the form of nano-sized particles, preferably having an effective particle size in the range 10 to 1000 nm is described. Also described is a method of making the composition and the use of the composition to as a medicament. Providing the composition in a pressurised dispenser having a meter for issuing a metered dose is also provided. The composition is suited for administration to the rectum, colon and/or terminal ileum of a patient for the treatment, prophylaxis, or maintenance of a disorder of the rectum, colon, terminal ileum or anus. The composition may further comprise an aqueous or non-aqueous vehicle which may be one or more phannaceutically acceptably alkanols; one or more pharmaceutically acceptable vegetable oils; or one or more phannaceutically acceptable organic esters and may further comprise surfactants, solubilizers, emulsifiers, antioxidant, preservatives, silicones, and/or 5-acetyl salicylic acid. Particularly the water soluble alkanols may be ethanol; propylene glycol; glycerol; polyethyleneglycol; polypropylene glycol; propylene glycol; a glyceryl ester; or a mixture thereof. The compositions may be prepared by: (1) heating a mixture of emulsifier and surfactant to form an oily phase; (2) separately heating a mixture of a preservative and water; (3) adding a water soluble alkanol to the preservative-water mixture and then mixing with oily phase of step (1); and (4) Adding rifaximin in the form of nanosized particles to the above mixture under stirring and adjusting the required pH to a desired value using a pH adjusting agent.
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