http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-600084-A
Outgoing Links
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| filingDate | 2010-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67724fb6ccf53b6ad8eccce3b97eac4e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54b21c69a9183b7255a4780bed7f6c50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d11ed363555558cad09dca3f9926418d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3fa12bfd5dcee83f6e8eb331d048e56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64f5835c9ed2d6470910042e2485bf61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d517ef1240b88885dc2dc420c6e6966c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e54df14b614f085d05d775e36cc2756 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92d6007a3217d9e30936b98169a36563 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4a77f44938b9efa14bc91fadd50496a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64b6eb1d5a3f8b699c241a8d9da861b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d7d2efe13daf94411183d13f7334121 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb945bb5404c9ff8c796f5707bc068bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bdb069dd52b62841fe7c1a1d9194046 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03e8d82204fb9d2556e037e865c298b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_716166df2ee90110dd7d454c932b41f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c56159e80f5bc4cd942a7b810bd84d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a26470f3b5dbb5f086cb535eda2b4804 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92a1fef763568cc14e84883780794304 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_063dd3899d19d46f6f96f6177491c7be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af724e4be201e488977b185966e84d54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f020d7405292462eb7ef54c425b2cf8b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eface3a4b802998d3f87b3b068c8a223 |
| publicationDate | 2014-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-600084-A |
| titleOfInvention | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| abstract | 600084 Disclosed are 2-(1H-indol-5-yloxy) / 2-(1H-indazol-4-yloxy) / 2-[(3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-4-yl)oxy and 2-[(6-amino-5-chloropyridin-3-yl)oxy] N-({ pyridin-3-yl / phenyl} sulfonyl)benzamide derivatives as represented by the general formula (I), wherein the compounds are N-({ 3-chloro-4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]phenyl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1H-indol-5-yl)oxy]benzamide; N-({ 3-chloro-4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]phenyl} sulfonyl)-4-(4-{ [4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1Hindol-5-yl)oxy]benzamide; N-({ 5-chloro-6-[(trans-4-hydroxycyclohexyl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1H-indazol-4-yl)oxy]benzamide; N-({ 5-chloro-6-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1H-indazol-4-yl)oxy]benzamide; tert-butyl 5-[(4-{ 4-[({ 5-chloro-6-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]pyridin-3-yl} sulfonyl)carbamoyl]-3-[(6-fluoro-1H-indol-5-yl)oxy]phenyl} piperazin-1-yl)methyl]-4-(4-chlorophenyl)-3,6-dihydropyridine-1(2H)-carboxylate; N-({ 5-chloro-6-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [4-(4-chlorophenyl)-1-(1,3-difluoropropan-2-yl)-1,2,5,6-tetrahydropyridin-3-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1H-indol-5-yl)oxy]benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1H-indazol-4-yl)oxy]-N-[(4-{ [(4-fluorotetrahydro-2H-pyran-4-yl)methyl]amino} -3-nitrophenyl)sulfonyl]benzamide; N-({ 5-chloro-6-[(trans-4-hydroxycyclohexyl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(7-fluoro-1H-indazol-4-yl)oxy]benzamide; N-({ 5-chloro-6-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(7-fluoro-1H-indazol-4-yl)oxy]benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-{ [3-nitro-4-({ [4-(oxetan-3-yl)morpholin-2-yl]methyl} amino)phenyl]sulfonyl} benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1H-indol-5-yl)oxy]-N-{ [3-nitro-4-({ [4-(oxetan-3-yl)morpholin-2-yl]methyl} amino)phenyl]sulfonyl} benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(7-fluoro-1H-indazol-4-yl)oxy]-N-[(4-{ [(4-fluorotetrahydro-2H-pyran-4-yl)methyl]amino} -3-nitrophenyl)sulfonyl]benzamide; N-({ 5-chloro-6-[(trans-4-hydroxy-4-methylcyclohexyl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1Hindazol-4-yl)oxy]benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-{ [5-chloro-6-(tetrahydro-2H-pyran-4-ylmethoxy)pyridin-3-yl]sulfonyl} -2-[(3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-4-yl)oxy]benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl} sulfonyl)-2-[(3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-4-yl)oxy]benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [(trans-4-methoxycyclohexyl)methyl]amino} -3-nitrophenyl)sulfonyl]-2-[(3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-4-yl)oxy]benzamide; 2-[(3-amino-1H-indazol-4-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [(4-fluorotetrahydro-2H-pyran-4-yl)methyl]amino} -3-nitrophenyl)sulfonyl]benzamide; 2-[(3-amino-1H-indazol-4-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl} sulfonyl)benzamide; 2-[(3-amino-1H-indazol-4-yl)oxy]-N-({ 5-chloro-6-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)benzamide; 2-[(3-amino-1H-indazol-4-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl} sulfonyl)benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [4-fluoro-1-(oxetan-3-yl)piperidin-4-yl]methoxy} -3-nitrophenyl)sulfonyl]benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1H-indazol-4-yl)oxy]-N-({ 4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl} sulfonyl)benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino} -3-nitrophenyl)sulfonyl]benzamide; 2-[(3-amino-1H-indazol-4-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [(trans-4-methoxycyclohexyl)methyl]amino} -3-nitrophenyl)sulfonyl]benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 4-[(cis-4-hydroxy-4-methylcyclohexyl)methoxy]-3-nitrophenyl} sulfonyl)benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [(cis-4-hydroxy-4-methylcyclohexyl)methyl]amino} -3-nitrophenyl)sulfonyl]benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-{ [3-chloro-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]sulfonyl} -2-[(3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-4-yl)oxy]benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [(4-cyclopropylmorpholin-2-yl)methyl]amino} -3-nitrophenyl)sulfonyl]-2-[(3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-4-yl)oxy]benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-{ [3-nitro-4-(2-oxaspiro[3.5]non-7-ylmethoxy)phenyl]sulfonyl} benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 4-[(trans-4-hydroxy-4-methylcyclohexyl)methoxy]-3-nitrophenyl} sulfonyl)benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-{ [4-({ [(2S)-4-cyclopropylmorpholin-2-yl]methyl} amino)-3-nitrophenyl]sulfonyl} benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-N-({ 5-chloro-6-[(trans-1-fluoro-4-hydroxy-4-methylcyclohexyl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-N-({ 5-chloro-6-[(cis-1-fluoro-4-hydroxy-4-methylcyclohexyl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)benzamide; 2-[(3-amino-1H-indazol-4-yl)oxy]-N-({ 5-chloro-6-[(trans-4-hydroxy-4-methylcyclohexyl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)benzamide; N-({ 5-chloro-6-[(trans-4-hydroxy-4-methylcyclohexyl)methoxy]pyridin-3-yl} sulfonyl)-2-[(3-chloro-1H-indazol-4-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [(cis-4-ethyl-4-hydroxycyclohexyl)methyl]amino} -3-nitrophenyl)sulfonyl]benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-{ [3-nitro-4-({ [(2S)-4-(oxetan-3-yl)morpholin-2-yl]methyl} amino)phenyl]sulfonyl} benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 5-nitro-6-[(tetrahydro-2H-pyran-4-ylmethyl)amino]pyridin-3-yl} sulfonyl)benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 3-nitro-4-[(2-oxaspiro[3.5]non-7-ylmethyl)amino]phenyl} sulfonyl)benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-{ [4-({ [trans-4-(morpholin-4-yl)cyclohexyl]methyl} amino)-3-nitrophenyl]sulfonyl} benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [cis-4-(morpholin-4-yl)cyclohexyl]amino} -3-nitrophenyl)sulfonyl]benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 5-cyano-6-[(trans-4-hydroxy-4-methylcyclohexyl)methoxy]pyridin-3-yl} sulfonyl)-2-[(6-fluoro-1Hindazol-4-yl)oxy]benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-{ [4-({ [4-({ [4-(methoxymethyl)cyclohexyl]methyl} amino)-3-nitrophenyl]sulfonyl} amino)-3-nitrophenyl]sulfonyl} benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(3-nitro-4-{ [(3R)-1-(oxetan-3-yl)pyrrolidin-3-yl]amino} phenyl)sulfonyl]benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(3-nitro-4-{ [(3S)-1-(oxetan-3-yl)pyrrolidin-3-yl]amino} phenyl)sulfonyl]benzamide; N-[4-({ 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)benzoyl} sulfamoyl)-2-nitrophenyl]morpholine-4-carboxami |
| priorityDate | 2009-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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