| abstract |
Disclosed herein is a compound of Formula (1) as described herein or a pharmaceutically acceptable salt thereof. The compounds are useful as inhibitors of the Human Double Minute 2 (HDM2) protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same. In one embodiment the compound is 3-(4-hydroxy-4-(2-methoxyphenyl)-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-2-yl)propanoic acid. |