| abstract |
598918 Disclosed are bicyclic condensed diazepine derivative compounds and pharmaceutical compositions thereof for the treatment of atrial fibrillation. Compounds of the disclosure include: 1-ethyl-3,3,5-trimethyl-7-(3-{ N-[2-(2-methyl-4-oxo-4H-furo[3,2-c]pyridin-5-yl)ethyl]-N-(pyridin-4-ylmethyl)amino} propyl)-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione, N-(1-ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-7-ylmethyl)-4-methyl-N-(2-pyridin-3-ylethyl)benzamide, N-(1-ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-7-ylmethyl)-N-(2-pyridin-3-ylethyl)benzenesulfonamide, and N-(2-{ [(1-ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-7-ylmethyl)(2-pyridin-3-ylethyl)amino]methyl} phenyl)methanesulfonamide. |