| abstract |
598685 Disclosed herein are pyrrolidine derivatives of formula (I), wherein X, Y, Z, R1, R2 and R3 are as defined herein, as inhibitors of glutaminyl cyclase, and the use thereof in the treatment of rheumatoid arthritis, atherosclerosis, pancreatitis and restenosis. Further disclosed is a pharmaceutical composition comprising a pyrrolidine derivative of formula (I) which additionally comprises at least one compound, selected from the group consisting of neuroprotectants, antiparkinsonian drugs, amyloid protein deposition inhibitors, beta amyloid synthesis inhibitors, antidepressants, anxiolytic drugs, antipsychotic drugs and anti-multiple sclerosis drugs. Specific embodiments of the compound include: 5-tert-butyl-1-(1H-benzo[d]imidazol-5-yl)imidazolidin-2-one, 1-(1H-benzo[d]imidazol-5-yl)-5-(2-chlorophenyl)imidazolidin-2-one, (S)-4-(1H-benzo[d]imidazol-6-yl)-5-(4-propoxyphenyl)morpholin-3-one, and (8)-1-(1H-benzo[d]imidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one, |