| abstract |
Disclosed are compositions comprising nanoparticles comprising a taxane and albumin and their use in the manufacture of a medicament for treating cancer in combination with a hedgehog inhibitor. The nanoparticle comprising taxane and albumin and the hegehog inhibitor can be administered simultaneously or sequentially, and gemcitabine can also be co-administered. Taxanes useful in the invention are docetaxel and paclitaxel. Particular cancers which can be treated with the use of the medicament inlcude basal cell carcinoma, medulloblastoma, glioblastoma, multiple myeloma, chronic myelogenous leukemia (CML), acute myelogenous leukemia, pancreatic cancer, lung cancer, esophageal cancer, stomach cancer, billary cancer, prostate cancer, liver cancer, hepatocellular cancer, gastrointestinal cancer, gastric cancer, ovarian cancer, and bladder cancer. |