| abstract |
Patent No. 598061 Disclosed is the use of compound 1 such as N-[6-(4-{ [2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]ethylamino} -2-methoxyphenoxy)pyridin-3-yl]-3,4-dichlorobenzamide and N-[6-(4-{ [2-(4-piperonylpiperazin-1-yl)-2-oxoethyl]ethylamino} phenoxy)pyridin-3-yl]-4-trifluoromethylbenzamide for the manufacture of a medicament for treating diseases associated with activation of STAT3 and/or STAT5 such as autoimmune blood dyscrasia, rheumatism, systemic lupus erythematosus, polychondritis, scleroderma, Wegener's granulomatosis, dermatomyositis, chronic active hepatitis, severe myasthenic, Stevens-Johnson syndrome, idiopathic sprue, inflammatory bowel disease, endocrine ophthalmopathy, Graves' disease, sarcoidosis, multiple sclerosis, primary biliary cirrhosis, uveitis, keratoconjunctivitis sicca, vernal keratoconjunctivitis, psoriatic arthritis, glomerulonephritis, diabetes, infection, central disease, cancer-associated disease, psoriasis, allergy or hyperprolactinemia. |