| abstract |
597983 Disclosed are compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein: W is O, NH, N(C1-C10 alkyl) or S; each X is independently CH or N; R1 is a 5 to 7- membered saturated or unsaturated, optionally substituted heterocycle containing at least 1 heteroatom selected from N or O; R2 is (LQ)m Y; and each R3 is independently H, C1-C10 alkyl, aryl or heteroaryl, are found to be inhibitors of PI3K-p110 delta. Compounds of the disclosure include: 8-Azetidin-1-ylmethyl-2-(1H-indol-4-yl)-4-morpholin-4-ylpyrido[3’,2’:4,5]furo[3,2-d]pyrimidine Cyclopropyl-[2-(1H-indol-4-yl)-4-morpholin-4-ylpyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-8-ylmethyl]-methyl-amine 3-{ 4-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-8-ylmethyl]-piperazin-1-yl} -propionitrile And 8-(4-Fluoro-piperidin-1-ylmethyl)-2-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3’,2’:4,5]furo[3,2-d]pyrimidine |