http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-597528-A
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_40765ca9a78b54a8a76f781d159ad145 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4436 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
filingDate | 2010-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32165ccc7d857a160c875bae8f30fd71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49f1539eb8de9e3d018d9f8cc2237a59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0c20f623041ca949d60791fd7f63ca0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f635bb33ac885bbd32a2e3f7b89639dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2b0b172641870f3bc17b08d45469842 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_952982885aec286344cef45bcea29a7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9932fbaada50f0cf74da661ce0fb82da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27f1cb0ec67ca9b141a74e95b65ccbda http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41ce955490e685b6c5d8c7e4a7fe8ed4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cb0fbb207bedf63f087265120d68886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d1868112bf5302462b612e02d8f5160 |
publicationDate | 2014-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | NZ-597528-A |
titleOfInvention | Inhibitors of flaviviridae viruses |
abstract | Disclosed are 5-(3,3-dimethyl-but-1-ynyl)-3-{ (cyclohexylcarbonyl)-amino} -thiophene-2-carboxylic acid derivatives as represented by the general formula (I), or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from the group consisting of optionally substituted alkyl, and optionally substituted saturated cycloalkyl; R2 is optionally substituted saturated or partially unsaturated cycloalkyl; wherein, each substituted R2 is substituted with one or more members independently selected from the group consisting of alkyl and OH; R3 is selected from the group consisting of optionally substituted alkylene, saturated cycloalkylene, substituted saturated cycloalkylene, optionally substituted arylene, and optionally substituted heterocyclylene; L is selected from the group consisting of O, S, S(O), and S(O)2; Het is an optionally substituted 3-12 membered heterocyclyl or optionally substituted 5-10 membered heteroaryl, wherein said 5 optionally substituted 3-12 membered heterocyclyl or optionally substituted 5-10 membered heteroaryl comprises one to four heteroatoms selected from O, S, or N; and wherein the remaining substituents are as defined herein. Also disclosed are representative compounds including 5-(3,3-dimethyl-but-1-ynyl)-3-{ (trans-4-methyl-cyclohexanecarbonyl)-[trans-4-(6-methyl-pyridazin-3-yloxy)-cyclohexyl]-amino} -thiophene-2-carboxylic acid, 5-(3,3-dimethyl-but-1-ynyl)-3-{ (trans-4-methyl-cyclohexanecarbonyl)-[trans-4-(6-oxo-1,6-dihydropyridazin-3-yloxy)-cyclohexyl]-amino} -thiophene-2-carboxylic acid, 5-(3,3-dimethyl-but-1-ynyl)-3-{ (trans-4-methyl-cyclohexanecarbonyl)-[trans-4-(4-pyrrolidin-1-ylmethyl-pyridin-2-yloxy)-cyclohexyl]-amino} -thiophene-2-carboxylic acid, 5-(3,3-dimethyl-but-1-ynyl)-3-[(trans-4-methyl-cyclohexanecarbonyl)-[1-(S)-methyl-3-(4-pyrrolidin-1-yl-methyl-pyridin-2-yloxy)-propyl]-amino]-thiophene-2-carboxylic acid, 3-(N-(4-(4-cyclopropyl-4H-1,2,4-triazol-3-ylthio)cyclohexyl)-4-methylcyclohexanecarboxamido)-5-(3,3-dimethylbut-1-ynyl)thiophene-2-carboxylic acid, 5-(3,3-dimethylbut-1-ynyl)-3-(4-methyl-N-(4-(1-methyl-1H-tetrazol-5-ylthio)cyclohexyl)cyclohexanecarboxamido)thiophene-2-carboxylic acid, 5-(3,3-dimethylbut-1-ynyl)-3-(4-methyl-N-(4-(1-methyl-1H-tetrazol-5-ylsulfonyl)cyclohexyl)cyclohexanecarboxamido)thiophene-2-carboxylic acid, 5-(3,3-dimethylbut-1-ynyl)-3-(4-methyl-N-(4-(pyridazin-4-yloxy)cyclohexyl)cyclohexanecarboxamido)thiophene-2-carboxylic acid, 5-(3,3-dimethylbut-1-ynyl)-3-((1R,4R)-4-methyl-N-((1R,4R)-4-(tetrahydro-2H-pyran-4-yloxy)cyclohexyl)cyclohexanecarboxamido)thiophene-2-carboxylic acid and 5-(3,3-dimethyl-but-1-ynyl)-3-{ (1R)-4-methylcyclohex-3-enecarbonyl)-[4-(tetrahydro-furan-3(S)-yloxy)-trans-cyclohexyl]-amino} -thiophene-2-carboxylic acid and 3-[[4-(4-dimethylaminomethyl-pyridin-2-yloxy)-cyclohexyl]-(4-methylene-cyclohexanecarbonyl)-amino]-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylic acid. Further disclosed is a pharmaceutical composition comprising a therapeutically effective amount of a compound as defined above, and a pharmaceutically acceptable carrier or excipient, for treating a viral infection caused by a Hepatitis C virus. |
priorityDate | 2009-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 75.