| abstract |
595832 Disclosed herein is a compound of formula 1a, wherein the variables are defined in the specification, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer or tautomer thereof; and the use thereof in the treatment of a CCR3-related disorder, disease or condition, such as an inflammatory or immunoregulatory disorder or disease, asthma, rhinitis, an allergic disease, or an autoimmune pathology, or HIV, lung granuloma, or Alzheimer’s disease. In one embodiment the compound is 1-(2-(3,5-dichlorophenoxy)-5-nitrophenylsulfonyl)-4,5-dimethylpiperazine. |