| abstract |
Disclosed herein are mercaptoquinoline compounds of the formula (1), wherein the variables are defined in the specification, and the use thereof in the treatment of pain, epilepsy, anxiety, dependency, mania, bipolar disorders, migraine, cognitive diseases, dystonia-associated dyskinesias and/or urinary incontinence. Exemplary compounds include: 2-cyclohexyl-N-(2-(2-(phenylsulfonyl)ethylthio)quinolin-3-yl)acetamide; N-(2-(ethylthio)quinolin-3-yl)-3,3-dimethylbutanamide; 3-cyclopentyl-N-(2-ethylsulfanyl-quinolin-3-yl)-propionamide; and N-[2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinolin-3-yl]-2-thiophen-2-yl-acetamide. |