| abstract |
Disclosed herein are compounds of the general formula (I), where the variables are define in the specification, for use in the treatment of pain, in particular acute pain, visceral pain, neuropathic pain, chronic pain and or inflammation pain; migraine; diabetes; diseases of the respiratory tract; inflammatory intestinal diseases; neurological diseases; neurodegenerative diseases, fibrotic diseases, inflammations of the skin; rheumatic diseases; septic shock; reperfusion syndrome; obesity and or as an angiogenesis inhibitor. Examples of the compounds disclosed herein are: 2-chloro-N-[(1R)-6-(8-pyridin-4-yl-3,8-diazaspiro[4.5]decane-3-carbonyl)-2,3-dihydro-1H-inden-1-yl]-benzamide; (E)-3-(2-chlorophenyl)-N-[2,2-dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydro-inden-1-yl]-acrylamide; N-[2,2-Dimethyl-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)-1,3-dihydro-inden-1-yl]-2,6-dimethyl-benzamide; and 2-Chloro-N-[6-[8-[(2-dimethylamino-pyrimidin-5-yl)-methyl]-2,8-diazaspiro[4.5]decane-2-carbonyl]-2,3-dihydro-IH-inden-1-yl]-6-fluoro-benzamide. |