| abstract |
593695 Provided are alkaloid aminoester derivatives of formula (I) where R1, R2, R3 and R6 are described in the specification. An example of a preferred derivative is (R)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-3-(2-phenyl-2-(phenylamino)acetoxy)-1-azonia-bicyclo[2.2.2]octane trifluoroacetate. The derivatives act as muscarinic receptor antagonists and induce bronchodilation. Further provided are methods of preparing the derivatives, pharmaceutical compositions comprising them and their therapeutic use thereof, including in the treatment of broncho-obstructive or inflammatory respiratory diseases. A device comprising the pharmaceutical compositions which is a single-dose or multi-dose dry powder inhaler, or a metered dose inhaler or a soft mist nebulizer is also provided. |