| abstract |
ABSTRACT - 593657 The disclosure relates to a liquid enema preparation suitable for administration intra-colonically which comprises a photosensitiser which is a 5-aminolevulinic acid (5-ALA) ester, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier or excipient and which further comprises: (a) one or more viscosity enhancing agents; and optionally one or more of the following: (b) one or more mucoadhesive agents or one or more mucolytic agents; (c) one or more penetration enhancers; and (d) one or more chelating agents; wherein the viscosity of the preparation increases after instillation into the area of interest. This enema preparation is suitable for the photodynamic treatment or diagnosis of cancer or non-cancerous conditions in the lower part of the gastrointestinal tract selected from inflammatory bowel disease, ulcerative colitis, Crohn's disease and irritable bowel syndrome |