abstract |
Disclosed is a modified factor VII (FVII) polypeptide comprising a modification in a FVII polypeptide, allelic and species variant thereof or active fragments thereof, wherein the modification is an amino acid insertion, deletion or replacement at a position corresponding to position D196, K197 or K199, and wherein the replacement is by a hydrophobic or acidic amino acid selected from Val, Leu, Ile, Phe, Trp, Met, Tyr, Cys, Asp, and Glu, and the modified FVII polypeptide exhibits increased coagulant activity and/or increased resistance to inhibitors compared to an unmodified FVII polypeptide. |