| abstract |
Disclosed is a process for the preparation of a polymer conjugate of an indolocarbazole compound of formula (I), wherein the substituents are as described within the specification, whereby the process comprises reacting a w-1H-imidazole-carboxamide with an indolocarbazole compound of formula (III). Further disclosed is a polymer conjugate of a compound of formula (I), a pharmaceutical composition comprising said polymer conjugate, and the use of said polymer conjugate in the manufacture of a medicament for the prevention, alleviation or/and treatment of HMGB-1 associated pathologies, such as atherosclerosis, tumours and neurodegenerative diseases. |