| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac2c17e532220d91aca9a28ef60f178b |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-485
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-7023
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4353
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-12 |
| filingDate |
2009-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9618394954b07050c83bdb07455c57a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b585f4f57a52a500c7f575cefb5512f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_858e13f7d6ec61b2a83d1a916c20d51a |
| publicationDate |
2013-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
NZ-593102-A |
| titleOfInvention |
Dihydroetorphines and their preparation |
| abstract |
Abstract - 593102 Disclosed is a process for the preparation of a compound of formula (VI) such as S-dihydroetorphine, or a salt thereof, wherein: R1 and R2 are independently C1-8straight-chained alkyl and * represents a (S) stereocentre) comprising reacting a compound of formula (IV) with a compound of formula R2M(X)p, wherein R2 is C1-8 straight-chained alkyl, M is a metal, X is halide and p is 1 or 0 (and preferably where R2M(X)p is MeMgBr) to produce a compound of formula (V) and hydrolysing said compound of formula (V). Also disclosed is a process of preparing a compound of (IV) (such as 20-ethyldihydrothevinone) which includes reacting thebaine with a compound such as 1-hexen-3-one to give 20-?-ethylthevinone, followed by a hydrogenation reaction. Also disclosed is a compound of formula (V) which is (S)-19-propyldihydrothevinol. |
| priorityDate |
2008-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |