http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-593088-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-34 |
| filingDate | 2009-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d4b91b03e4cfc3bc5ada888ba855657 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a61c0b50716a4aeb73cd8a1e20f6c4a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_decdbd6193ab73c633cc9f7edfc982d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff44b7ce7fe89adb8e625ce5a31e53bb |
| publicationDate | 2012-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-593088-A |
| titleOfInvention | 8-([Hetero]aryl)-6-(4-alkyl-piperazin-1-yl)-9H-purine derivatives and uses thereof in the treatment of pain |
| abstract | Disclosed are 8-([Hetero]aryl)-6-(4-alkyl-piperazin-1-yl)-9H-purine derivatives as represented by the general formula (I), wherein R1 is selected from H, F, Cl, alkyl, CF3, cyclopropyl, OCH3, OCF3 and CN; R2 is selected from tetrahydrofuranyl, tetrahydropyranyl, azetidine-1-carboxylic acid methyl ester and tetrahydrothiophene-1,1-dioxide; R3 is H or combines with R4 to form a fused pyrrolidin-2-one; R4 is selected from alkyl, fluoroalkyl, cyclopropyl and COCH3; R5 is selected from H, CH3 and CF3; n is 0 or 1; X1 and X3 are independently selected from N, CH and CR6; X2 is selected from CH and CR6; with the proviso that only one of X1, X2 and X3 may be other than CH; R6 is selected from F, Cl, CF3, OCH3 and OCF3; or a pharmaceutically acceptable salt thereof. Representative compounds include 8-(2-chloro-pyridin-3-yl)-2-methyl-6-(4-methyl-piperazin-1-yl)-9-(R)-tetrahydro-furan-3-yl-9H-purine, 2-methyl-6-(4-methyl-piperazin-1-yl)-9-(tetrahydro-pyran-4-yl)-8-(2-trifluoromethylphenyl)-9H-purine and 8-(2-chloro-phenyl)-2-methyl-6-(4-methyl-piperazin-1-yl)-9-(tetrahydro-pyran-4-yl)-9H-purine. Also disclosed is a pharmaceutical composition which comprises a compound as defined above, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable diluent or carrier, for the treatment of pain and osteoarthritic pain. |
| priorityDate | 2008-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.