| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_78250a4b8255d1ae53ef942ef350fb6f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-554
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-542
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate |
2009-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_999e5cf13b72e330650bdc57c3181b14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be6762480f67d4691ebe753480a4e0db
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa65199072aeb26abacdad4c5c10151c |
| publicationDate |
2013-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
NZ-592738-A |
| titleOfInvention |
APJ receptor compounds attached to a lipophilic tether through a carbonyl linker |
| abstract |
Disclosed is a compound represented by Formula I: T-L-P, or pharmaceutically acceptable salts thereof, wherein: P is a peptide comprising at least thirteen contiguous amino-acid residues derived from an intracellular il loop of the APJ receptor; L is a linking moiety represented by C(O) and bonded to P at an N terminal nitrogen of an N-terminal amino-acid residue; and T is a lipophilic tether moiety bonded to L where the C-terminal amino acid residue of P is optionally functionalized, wherein P is derived from the il loop and is represented by the following structural formula or pharmaceutically acceptable salts thereof, X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15-X16-X17-X18-X19-Ri, wherein: X1 is absent or a threonine; X2 is absent or a valine; X3 is absent or a phenylalanine; X4 is absent or an arginine; X5 is a serine; X6 is a serine; X7 is an arginine; X8 is a glutamic acid; X9 is a lysine; X10 is an arginine; X11 is an arginine; X12 is a serine; X13 is an alanine; X14 is an aspartic acid; X15 is an isoleucine; X16 is a phenylalanine; X17 is an isoleucine; X18 is absent or an alanine; X19 is absent or a serine residue; Ri is OR2 or N(R2)2; each R2 is independently hydrogen or (C1-C10)alkyl; and from 0 to 1 amino acid residues are present in the D configuration and wherein from 0 to 1 amino acid residues may be substituted by alanine |
| priorityDate |
2008-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |