http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-592686-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97c71b09235336e87e31f355e84098a1 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C259-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-167 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C259-06 |
| filingDate | 2009-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd37f761fb82b1a8d1f8c0926d457f6b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59902c4b3efbb59cabac4872d4c2d3f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_425501e94097c23494c911499e5f8693 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3347d9b24c8f825dcde835aa3fc8523 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7beeb8d1e61924d187c4df7f537992f |
| publicationDate | 2012-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-592686-A |
| titleOfInvention | Process for the preparation of vorinostat from aniline, hydroxylamine and suberic acid starting materials |
| abstract | Disclosed is a process for the preparation of vorinostat (also known as N-hydroxy-N'-phenyl-octanediamide or suberoylanilide hydroxamic acid (SAHA)), comprising: (a) reacting suberic acid with aniline, or a salt thereof, to form suberanilic acid; and (b) reacting the suberanilic acid formed in step (a) with hydroxylamine, or a salt thereof; or (a') reacting suberic acid with hydroxylamine, or a salt thereof, to form N-hydroxy-7-carboxy-heptanamide; and (b) reacting the N-hydroxy-7-carboxy-heptanamide formed in step (a') with aniline, or a salt thereof; wherein step (a) involves a coupling agent selected from 1,3-dicyclohexylcarbodiimide (DCC); 1,1'-carbonyldiimidazole (CDI); 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (WSC.HC1); 1,3-diisopropylcarbodiimide (DIC); or a mixture thereof; and wherein step (b) involves a coupling agent selected from 1,3-dicyclohexylcarbodiimide (DCC); 1,1'-carbonyldiimidazole (CDI); 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (WSC.HCI); 1,3-diisopropylcarbodiimide (DIC); or a mixture thereof. |
| priorityDate | 2008-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.