| abstract |
Disclosed is a process of preparing enantiomerically enriched (S)-pregabalin by chiral resolution, comprising the use of an enantiomer of tartaric acid, camphor-10-sulphonic acid, camphor-3-sulphonic acid, 3-bromo-camphor-9-sulphonic acid, 2-keto-gulonic acid, ??methoxyphenylacetic acid, 2-nitrotartranilic acid, malic acid, 2-phenoxypropionic acid, N-acetylleucine, N-((?-methylbenzyl)succinamic acid, N-(?-methylbenzyl)phthalamic acid, quinic acid, di-O-isopropylidene-2-oxo-L-gulonic acid, 2-hydroxy-4-isopropenyl-1-methyl-cyclohexane-1-sulphonic acid, or O,O'-di-p-toluoyl-(L)-tartaric acid, O,O'-dibenzoyl-(L)-tartaric acid, (S)-3-chloro-mandelic acid or (S)-3-bromo-mandelic acid as an acid resolving agent. |