| abstract |
The disclosure relates to an efficient, high-yielding process for the preparation of dihydro-thieno[3,2-d]pyrimidine diols represented by formula (I), and similar pyrimidine diols of formula (X), wherein the process does not require expensive and potentially unstable intermediates. These diols are used as intermediates in the synthesis of pyrimidine compounds which inhibit PDE4, and are thus useful in the treatment of respiratory or gastrointestinal diseases and complaints, peripheral or central nervous system diseases and disorders, inflammatory conditions, and cancers. |