| abstract |
Disclosed are compounds useful as AMPK modulators represented by formula I or II, wherein the substituents are as described within the specification. Examples of the disclosed compounds include: 5-(2,6-Dihydroxybiphenyl)-1H-indole-3-carbonitrile; and 5-(6-(2-Hydroxyphenyl)pyridazin-3-yl)-1H-indole-3-carbaldehyde. Further disclosed is a pharmaceutical composition comprising a therapeutically effective amount of a compound of formula I or II, and the use of a compound of formula I or II in the manufacture of a medicament for regulating AMPK, and for the treatment of diabetes, obesity and cancer. |