| abstract |
Disclosed are compounds of formula (I) e.g. (3S)-1-methyl-piperidin-3-yl-(4-bromophenyl)carbamate wherein R1 represents a hydrogen atom or a methyl group, R2 represents a bromine atom, a fluorine atom or a trifluoromethyl group, their enantiomers, and also addition salts thereof with a pharmaceutically acceptable acid or base for use in the treatment of deficiencies of memory associated with cerebral ageing and with neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Pick's disease, Korsakoffs disease, vascular dementias, frontal and sub-cortical dementias and also schizophrenia. Also disclosed is a process for the preparation of said compounds characterised in that there is used as starting material 3-hydroxy-1-methylpiperidine which is subjected to a step of protection of the nitrogen atom to yield the N-protected derivative wherein R' represents a protecting group for the amine function such as, for example, a tert-butyloxycarbonyl group, which is then subjected to the action of a para-halophenyl isocyanate, to yield 1-methylpiperidin-3-yl-(4-halophenyl)carbamate, which is then subjected to a reaction deprotecting the amine function, for example in the presence of trifluoroacetic acid, to yield the desired compound. |