abstract |
Provided is an isolated antibody that binds human hepcidin-25 with a KID of about 800 pM or less as determined by surface plasmon resonance (SPR) at 25 °C and comprises six CDRs consisting of LCDR1, LCDR2, LCDR3, HCDR1, HCDR2, and HCDR3 having specified amino acid sequences. The antibody can be used for increasing serum iron levels, reticulocyte count, red blood cell count, haemoglobin, or haematocrit in a subject. |