abstract |
A factor Xa polypeptide having the amino acid sequence of SEQ ID NO: 10, 11, 12 or 13. The polypeptides have (a) reduced procoagulant activity compared to wild-type factor Xa, (b) is capable of binding to a factor Xa inhibitor and (c) does not assemble into a prothrombinase complex. The polypeptide can be used to reduce bleeding in a subject undergoing anticoagulant therapy with a factor Xa inhibitor. |