| abstract |
Disclosed is a nucleic acid construct encoding three RNA molecules comprising a double-stranded region, wherein the RNA molecule reduces influenza A virus replication in an animal cell and/or reduces production of infectious influenza A virus particles in an animal cell and/or reduces the expression of an influenza A virus polypeptide in an influenza A virus infected animal cell when compared to an isogenic influenza A virus infected animal cell lacking the RNA molecules, wherein the double-stranded regions comprise nucleotide sequences at least 95% identical to sequences selected from: (i) SEQ ID NO:6, SEQ ID NO:7 and SEQ ID NO:8, and (ii) SEQ ID NO:7, SEQ ID NO:9 and SEQ ID NO:12. Also disclosed is the use of the nucleic acid construct in the manufacture of a medicament for treating and/or preventing influenza A virus infection. |