| abstract |
Disclosed are N-(8-heteroaryltetrahydronaphtalene-2yl) or N-(5-heteroarylchromane-3-yl) carboxamide derivative compounds of formula (I), wherein the substituents are as described in the specification. Examples of compounds of formula (I) included: N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]-4-(trifluoromethoxy)-benzamide; and 4-{ [(2R)-8-Pyridin-4-yl-1,2,3,4-tetrahydronaphthalen-2-yl]carbamoyl} phenyl trifluoromethanesulfonate. Further disclosed is the use of a compound of formula (I) in the manufacture of a medicament for the treatment of pain, and a pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (I). |